解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Sugarcane smut is a fungal disease caused by Sporisorium scitamineum. Cultivation of smut-resistant sugarcane varieties is the most effective way to control this disease. The interaction between sugarcane and S. scitamineum is a complex network system. However, to date, there is no report on the identificati...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5400-8
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5418-y
更新日期:2019-01-16 00:00:00
abstract:BACKGROUND:During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes. The evolutionary resolution to such dosage imbalance, as hypothesized by Susumu Ohno fifty years ago, should be doubling the expression of X-linked gene...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5432-8
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:Aging is affected by genetic and environmental factors, and cigarette smoking is strongly associated with accumulation of senescent cells. In this study, we wanted to identify genes that may potentially be beneficial for cell survival in response to cigarette smoke and thereby may contribute to development o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5409-z
更新日期:2019-01-09 00:00:00
abstract:BACKGROUND:Sequencing data has become a standard measure of diverse cellular activities. For example, gene expression is accurately measured by RNA sequencing (RNA-Seq) libraries, protein-DNA interactions are captured by chromatin immunoprecipitation sequencing (ChIP-Seq), protein-RNA interactions by crosslinking immun...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5362-x
更新日期:2019-01-05 00:00:00
abstract:BACKGROUND:Pekin duck products have become popular in Asia over recent decades and account for an increasing market share. However, the genetic mechanisms affecting carcass growth in Pekin ducks remain unknown. This study aimed to identify quantitative trait loci affecting body size and carcass yields in Pekin ducks. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5379-1
更新日期:2019-01-03 00:00:00
abstract:BACKGROUND:One of the most common and recurrent vaginal infections is bacterial vaginosis (BV). The diagnosis is based on changes to the "normal" vaginal microbiome; however, the normal microbiome appears to differ according to reproductive status and ethnicity, and even among individuals within these groups. The Amsel...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5284-7
更新日期:2018-12-31 00:00:00
abstract:BACKGROUND:Interactions among transcription factors (TFs) and histone modifications (HMs) play an important role in the precise regulation of gene expression. The context specificity of those interactions and further its dynamics in normal and disease remains largely unknown. Recent development in genomics technology e...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5278-5
更新日期:2018-12-31 00:00:00
abstract:BACKGROUND:NGS data contains many machine-induced errors. The most advanced methods for the error correction heavily depend on the selection of solid k-mers. A solid k-mer is a k-mer frequently occurring in NGS reads. The other k-mers are called weak k-mers. A solid k-mer does not likely contain errors, while a weak k-...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5272-y
更新日期:2018-12-31 00:00:00
abstract:BACKGROUND:A-to-I RNA editing is a co-/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I). Most of known editing events are located within inverted ALU repeats, but they also occur in coding sequences and may alter the function of encoded proteins. RNA editing ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5364-8
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5295-4
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:Betula platyphylla is a common tree species in northern China that has high economic and medicinal value. Our laboratory has been devoted to genome research on B. platyphylla for approximately 10 years. As primary organelle genomes, the complete genome sequences of chloroplasts are important to study the div...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5346-x
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:Bovine papillomavirus (BPV) belongs to the Papillomaviridae family and infects epithelial cells of bovines and closely related animals, causing hyperproliferative lesions known as warts or papillomas, which may regress or progress to form benign or malignant tumors. The virus enters the host cell and interac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5361-y
更新日期:2018-12-19 00:00:00
abstract:BACKGROUND:Democratising the growing body of whole genome sequencing data available for Triticum aestivum (bread wheat) has been impeded by the lack of a genome reference and the large computational requirements for analysing these data sets. RESULTS:DAWN (Diversity Among Wheat geNomes) integrates data from the T. aes...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5228-2
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:The sustainability of poultry farming relies on the development of more efficient and autonomous production systems in terms of feed supply. This implies a better integration of adaptive traits in breeding programs, including digestive efficiency, in order to favor the use of a wider variety of feedstuffs. T...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5344-z
更新日期:2018-12-13 00:00:00
abstract:BACKGROUND:Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes - and thus for conserved secondary structures - even in genomic reg...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5234-4
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND:Even though microsatellite loci frequently have been isolated using recently developed next-generation sequencing (NGS) techniques, this task is still difficult because of the subsequent polymorphism screening requires a substantial amount of time. Selecting appropriate polymorphic microsatellites is a criti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5329-y
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND:Pectobacterium spp. are necrotrophic bacterial plant pathogens of the family Pectobacteriaceae, responsible for a wide spectrum of diseases of important crops and ornamental plants including soft rot, blackleg, and stem wilt. P. carotovorum is a genetically heterogeneous species consisting of three valid sub...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5269-6
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND:Restriction-modification (R-M) systems protect bacteria and archaea from attacks by bacteriophages and archaeal viruses. An R-M system specifically recognizes short sites in foreign DNA and cleaves it, while such sites in the host DNA are protected by methylation. Prokaryotic viruses have developed a number ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5324-3
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND:Copy number variants (CNVs) have been shown to increase risk for physical anomalies, developmental, psychiatric and medical disorders. Some of them have been associated with changes in weight, height, and other physical traits. As most studies have been performed on children and young people, these effects o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5292-7
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:Taraxacum kok-saghyz R. (Tks) is a promising alternative species to Hevea brasiliensis for production of high quality natural rubber (NR). A comparative transcriptome analysis of plants with differential production of NR will contribute to elucidate which genes are involved in the synthesis, regulation and a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5287-4
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:Spinach downy mildew caused by the oomycete Peronospora effusa is a significant burden on the expanding spinach production industry, especially for organic farms where synthetic fungicides cannot be deployed to control the pathogen. P. effusa is highly variable and 15 new races have been recognized in the pa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5214-8
更新日期:2018-11-29 00:00:00
abstract:BACKGROUND:Photorhabdus luminescens is an enteric bacterium, which lives in mutualistic association with soil nematodes and is highly pathogenic for a broad spectrum of insects. A complete genome sequence for the type strain P. luminescens subsp. laumondii TT01, which was originally isolated in Trinidad and Tobago, has...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5121-z
更新日期:2018-11-29 00:00:00
abstract:BACKGROUND:Leishmaniasis is a neglected tropical disease with diverse clinical phenotypes, determined by parasite, host and vector interactions. Despite the advances in molecular biology and the availability of more Leishmania genome references in recent years, the association between parasite species and distinct clin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5271-z
更新日期:2018-11-28 00:00:00
abstract:BACKGROUND:Gene ontology analysis using the microarray database generated in a previous study by this laboratory was used to further evaluate how maternal dietary supplementation with pyridoxine combined with different sources of selenium (Se) affected global gene expression of expanded porcine blastocysts. Data were g...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5237-1
更新日期:2018-11-21 00:00:00
abstract:BACKGROUND:Despite its relevance, almost no studies account for the genetic control in the early stages of tree development, i.e. from germination on. This study seeks to make a quite complete transcriptome for olive development and to elucidate the dynamic regulation of the transcriptomic response during the early-juv...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5232-6
更新日期:2018-11-19 00:00:00
abstract:BACKGROUND:Anthocyanins are water-soluble colored flavonoids present in multiple organs of various plant species including flowers, fruits, leaves, stems and roots. DNA-binding R2R3-MYB transcription factors, basic helix-loop-helix (bHLH) transcription factors, and WD40 repeat proteins are known to form MYB-bHLH-WD rep...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5135-6
更新日期:2018-11-08 00:00:00
abstract:BACKGROUND:Rapeseed (Brassica napus) is an important oil seed crop in the Brassicaceae family. Chemical induced male sterility (CIMS) is one of the widely used method to produce the hybrids in B. napus. Identification of the key genes and pathways that involved in CIMS were important to understand the underlying molecu...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5203-y
更新日期:2018-11-07 00:00:00
abstract:BACKGROUND:Salmonella enterica is a significant foodborne pathogen, which can be transmitted via several distinct routes, and reports on acquisition of antimicrobial resistance (AMR) are increasing. To better understand the association between human Salmonella clinical isolates and the potential environmental/animal re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5137-4
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Fusion genes are known to be drivers of many common cancers, so they are potential markers for diagnosis, prognosis or therapy response. The advent of paired-end RNA sequencing enhances our ability to discover fusion genes. While there are available methods, routine analyses of large number of samples are st...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5156-1
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Understanding how and why genetic variation is partitioned across geographic space is of fundamental importance to understanding the nature of biological species. How geographical isolation and local adaptation contribute to the formation of ecotypically differentiated groups of plants is just beginning to b...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5179-7
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Understanding the underlying genetic structure of human populations is of fundamental interest to both biological and social sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation. The most widely used methods for col...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5168-x
更新日期:2018-10-29 00:00:00
abstract:BACKGROUND:The mitochondrial genomes of higher plants vary remarkably in size, structure and sequence content, as demonstrated by the accumulation and activity of repetitive DNA sequences. Incompatibility between mitochondrial genome and nuclear genome leads to non-functional male reproductive organs and results in cyt...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5122-y
更新日期:2018-10-26 00:00:00
abstract:BACKGROUND:An efficient signal transduction system allows a bacterium to sense environmental cues and then to respond positively or negatively to those signals; this process is referred to as taxis. In addition to external cues, the internal metabolic state of any bacterium plays a major role in determining its ability...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5151-6
更新日期:2018-10-19 00:00:00
abstract:BACKGROUND:Plant-bacteria associations have been extensively studied for their potential in increasing crop productivity in a sustainable manner. Serratia marcescens is a species of Enterobacteriaceae found in a wide range of environments, including soil. RESULTS:Here we describe the genome sequencing and assessment o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5130-y
更新日期:2018-10-16 00:00:00
abstract:BACKGROUND:Embryonic and fetal exposure to maternal obesity causes several maladaptive morphological and epigenetic changes in exposed offspring. The timing of these events is unclear, but changes can be observed even after a short exposure to maternal obesity around the time of conception. The hypothesis of this work ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5120-0
更新日期:2018-10-11 00:00:00
abstract:BACKGROUND:Biocontrol of bacterial pathogens by bacteriophages (phages) represents a promising strategy. Vibrio alginolyticus, a gram-negative bacterium, is a notorious pathogen responsible for the loss of economically important farmed marine animals. To date, few V. alginolyticus phages have been successfully isolated...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5131-x
更新日期:2018-10-11 00:00:00
abstract:BACKGROUND:The question of whether bacterial species objectively exist has long divided microbiologists. A major source of contention stems from the fact that bacteria regularly engage in horizontal gene transfer (HGT), making it difficult to ascertain relatedness and draw boundaries between taxa. A natural way to defi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5099-6
更新日期:2018-10-03 00:00:00
abstract:BACKGROUND:High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Aeromonas salmonicida, the causative agent of furunculosis. The vertebrate liver has multifaceted f...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5092-0
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Metal tolerance is often an integrative result of metal uptake and distribution, which are fine-tuned by a network of signaling cascades and metal transporters. Thus, with the goal of advancing the molecular understanding of such metal homeostatic mechanisms, comparative RNAseq-based transcriptome analysis w...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5109-8
更新日期:2018-09-26 00:00:00